The Interstitium: The Discovery of a Third Circulatory System

The Interstitium: The Body as an Interconnected Fluid Network
For generations, anatomy education described two primary fluid circulation systems within the human body:
The cardiovascular system, which circulates blood through arteries, veins, and capillaries.
The lymphatic system, which helps regulate fluid balance, immune activity, and waste removal.
Emerging research now suggests the body may also function through a third large-scale fluid network known as the interstitium — an interconnected system of fluid-filled spaces woven throughout connective tissue and fascia. Rather than seeing the body as isolated structures organized like separate compartments, this perspective reveals the body more as a continuous, communicating network.

